There is some evidence that there are biological differences in pathological gamblers, but it is unclear whether these differences are the cause of the disorder or caused by disorder.
Some research suggests that there may be a link between serotonin and norepinephrine problems and PG. Serotonin may be related to feelings of well being. Norepinephrine may play a role in the feelings of arousal associated with being "in action."
Some research has also found genetic differences in the dopamine receptor genes of pathological gamblers.